Overview

Diagnosis

Determining the cause of headaches can be challenging. Your healthcare provider will ask detailed questions about your headache patterns and perform a physical exam.

Imaging tests may be used to help identify the underlying cause:

  • CT scan: Combines X-ray images from multiple angles to create cross-sectional images of the brain and head, including the sinuses.

  • Magnetic resonance imaging (MRI): Uses a magnetic field and radio waves to produce detailed cross-sectional images of brain structures.

Treatment

Many people who think they have sinus headaches may actually have migraines or tension-type headaches. Treatment focuses on relieving symptoms and preventing future episodes.

Pain relievers

  • Over-the-counter medications such as acetaminophen, ibuprofen, or naproxen sodium may help reduce headache pain.

Triptans

  • Medications like sumatriptan, rizatriptan, almotriptan, naratriptan, zolmitriptan, frovatriptan, and eletriptan relieve migraine pain by blocking pain pathways in the brain.

  • Triptans can be taken as tablets, nasal sprays, or injections and should be avoided in people with heart disease or stroke.

  • A combination of sumatriptan and naproxen sodium has been shown to be more effective than either medication alone.

Ergots

  • Ergotamine with caffeine (Migergot) or dihydroergotamine (D.H.E. 45, Migranal) may be used if pain lasts longer than 72 hours.

  • These medications constrict blood vessels and can worsen nausea or cause medication-overuse headaches; they should be avoided in people with heart disease or stroke.

Newer therapies

  • Lasmiditan (Reyvow): Oral tablet for migraine with or without aura; blocks pain pathways without constricting blood vessels.

  • CGRP antagonists: Ubrogepant (Ubrelvy) and rimegepant (Nurtec ODT) for acute migraine treatment.

  • CGRP monoclonal antibodies: Erenumab, fremanezumab, galcanezumab, and eptinezumab are given monthly or quarterly by injection to prevent migraines.

Anti-nausea medications

  • Chlorpromazine, metoclopramide, or prochlorperazine may be used to control nausea often associated with migraines.

Glucocorticoids

  • Dexamethasone may be used alongside other medications for pain relief but should not be used frequently due to the risk of steroid toxicity.


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