Merkel Cell Carcinoma

Merkel cell carcinoma is a rare and aggressive type of skin cancer that can be life-threatening. It develops in Merkel cells found in your skin’s outer layer (your epidermis).

Exposure to ultraviolet (UV) light and other risk factors can cause these cells to become cancerous and grow uncontrollably. Merkel cell carcinoma tends to spread quickly to other parts of your body and often comes back after treatment.

What are Merkel cells?

Merkel cells are found deep in your epidermis (top layer of your skin). The cells are a type of neuroendocrine cell that has both nervous system and endocrine system functions. They sit near nerve endings that provide sense of touch and they have substances that act like hormones. German physician Friedrich Merkel first described these cells in the late 1800s.

How common is Merkel cell carcinoma?

Merkel cell carcinoma is a very rare type of skin cancer, affecting approximately 3,000 Americans every year.

However, the number of people receiving a Merkel cell carcinoma diagnosis is steadily increasing. This increase may be due to improved diagnostic tests. The condition also tends to affect people older than 70. As people live longer, they may be more likely to develop this cancer.

What are other names for Merkel cell carcinoma?

You may also hear these terms to refer to Merkel cell carcinoma:

• MCC.
• Merkel cell cancer.
• Neuroendocrine carcinoma of the skin.
• Trabecular cancer.