Adult Still Disease

Diagnosis of Adult Still Disease

There is no single test that can confirm adult Still disease. Doctors use a combination of approaches:

• Imaging tests: Reveal joint or tissue damage caused by the disease

• Blood tests: Help rule out other conditions with similar symptoms, including autoimmune or infectious disorders

Related tests may include:

• Antinuclear antibody (ANA) test

• C-reactive protein (CRP) test

• CT scan

Treatment of Adult Still Disease

Treatment depends on the severity of symptoms and potential side effects. Common treatment options include:

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs, such as ibuprofen (Advil, Motrin IB) or naproxen sodium (Aleve), can help with mild joint pain and inflammation.

• Stronger NSAIDs are available by prescription

• Regular liver function tests may be needed, as NSAIDs can affect the liver

Steroids

Steroids, such as prednisone, are used to reduce inflammation in more severe cases.

• May lower immunity, increasing infection risk

• Can raise the risk of osteoporosis and diabetes

Methotrexate

Methotrexate (Trexall) is often combined with prednisone to reduce steroid dosage while controlling inflammation effectively.

Biologic Response Modifiers

If other treatments are insufficient, biologic response modifiers (biologics) may be recommended. These medicines block proteins that cause inflammation.

Common biologics for adult Still disease include:

• Anakinra (Kineret)

• Canakinumab (Ilaris)

• Tocilizumab (Actemra)

• Others that may help: Etanercept (Enbrel), Infliximab (Remicade), Adalimumab (Humira), Rituximab (Rituxan)

When to Seek Care

Seek medical attention if you experience:

• Persistent high fevers or joint pain

• Unexplained rash

• Symptoms that interfere with daily activities

Early evaluation and treatment can prevent long-term joint damage and improve quality of life.