Primary Lateral Sclerosis (PLS)

A healthcare provider will diagnose PLS after a physical examination, a neurological examination and testing. They’ll review your symptoms to rule out look-alike conditions like ALS or multiple sclerosis. Diagnostic testing may include:

• Blood tests.
• Electrodiagnostic examination (nerve conduction and needle electrode studies), which measures how well your nerves and muscles are working.
• Magnetic resonance imaging (MRI) of your brain and spinal cord.
• A cerebrospinal fluid (CSF) analysis after a lumbar puncture (spinal tap) to look for abnormalities specific to neuromuscular conditions.