Overview
As thrombocytosis doesn’t typically cause symptoms, the first sign is often a high platelet count that shows up during routine blood work (complete blood count).
Thrombocytosis involves having more than 450,000 platelets per microliter of blood. If you have elevated levels, your healthcare provider will likely order a follow-up blood test a few weeks later to see if your levels remain high. Levels that are momentarily high but then return to normal aren’t usually concerning. Levels that remain elevated may signal an underlying condition.
Identifying the underlying condition (such as iron deficiency anemia, cancer or infection) that’s raising your levels helps healthcare providers diagnose and manage reactive thrombocytosis. If your provider can’t find a secondary cause, they’ll run tests to see if you have essential thrombocythemia.
Tests may include:
- Peripheral blood smear: Shows if the platelets in your blood look abnormal.
- DNA/genetic tests: Detect gene mutations common in ET, like JAK2.
- Bone marrow biopsy: Checks for abnormal cells in your bone marrow.
Symptoms
When to see a doctor
Complications
- High blood pressure.
- Diabetes.
- Heart failure.
- Some types of heart valve disease.
Prevention
- Control high blood pressure, high cholesterol and diabetes.
- Don't smoke or use tobacco.
- Eat a diet that's low in salt and saturated fat.
- Exercise at least 30 minutes a day on most days of the week unless your health care team says not to.
- Get good sleep. Adults should aim for 7 to 9 hours daily.
- Maintain a healthy weight.
- Reduce and manage stress.
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