Multiple Endocrine Neoplasia, Type 2 (MEN 2)

Overview

Multiple endocrine neoplasia, type 2, also called MEN 2, is a rare condition. It causes tumors in the thyroid and parathyroid glands, adrenal glands, lips, mouth, eyes and digestive tract. Genetic testing can find the changed gene that causes MEN 2. Health care providers can treat the health issues that gene may cause.

MEN 2 is an inherited disorder. This means people who have the changed gene can pass it on to their children. Each child has a 50% chance of getting the disorder.

Types

There are two types of MEN 2:

MEN 2A. This also is known as classical MEN 2A or Sipple syndrome. It causes medullary thyroid cancer and noncancerous tumors of the parathyroid glands and adrenal glands.
MEN 2B. This type of MEN 2 is rare. It causes medullary thyroid cancer, noncancerous tumors of the adrenal gland, and noncancerous tumors on the lips, on the tongue and in the digestive tract. MEN 2B does not cause problems with the parathyroid glands.

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Symptoms

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Complications

Blood clots are a dangerous complication of atrial fibrillation (AFib). Blood clots can lead to stroke.

The risk of stroke from AFib increases as you grow older. Other health conditions also may increase the risk of a stroke due to AFib. These conditions include:

High blood pressure.
Diabetes.
Heart failure.
Some types of heart valve disease.

Blood thinners are commonly prescribed to prevent blood clots and strokes in people with atrial fibrillation.

Prevention

Healthy lifestyle choices can reduce the risk of heart disease and may prevent atrial fibrillation (AFib). Here are some basic heart-healthy tips:

Control high blood pressure, high cholesterol and diabetes.
Don't smoke or use tobacco.
Eat a diet that's low in salt and saturated fat.
Exercise at least 30 minutes a day on most days of the week unless your health care team says not to.
Get good sleep. Adults should aim for 7 to 9 hours daily.
Maintain a healthy weight.
Reduce and manage stress.

By Mayo Clinic Staff

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Diagnosis & treatment

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