Myxofibrosarcoma

Myxofibrosarcoma (MFS) is a type of soft tissue sarcoma cancer that starts in connective tissues. Connective tissues include bones, cartilage and fat that provide structure and protection around your organs. MFS often grows in your arm or leg and may look like a small lump.

Myxofibrosarcoma may grow in connective tissues directly underneath your skin. Or it may grow in deeper connective tissues surrounding your muscles.

MFS is an aggressive tumor, meaning it spreads (metastasizes) quickly to other parts of your body. It’s more likely to grow back (recur) after treatment than some other types of cancers.

What is high-grade myxofibrosarcoma?

Healthcare providers use a grading scale to classify tumors. Low-grade tumors contain fewer cells that divide quickly, so these tumors grow and spread slowly. High-grade tumors have more dividing cells and grow quickly.

Who might get myxofibrosarcoma?

Myxofibrosarcoma is more common in adults over 50 and slightly more common in people designated male at birth (DMAB) than people designated female at birth (DFAB).

Other factors that can increase your risk of malignant soft tissue tumors, including MFS, include:

• Genetics: Some genetic conditions may increase your risk of soft tissue sarcomas.
• Environmental factors: Certain chemicals, such as arsenic and herbicides, can raise your risk.
• Radiation therapy: A history of radiation therapy may increase your risk of certain cancers, such as myxofibrosarcoma.

How common is myxofibrosarcoma?

Myxofibrosarcoma is rare. It’s one of the most common types of soft tissue sarcomas. However, soft tissue sarcomas make up only about 2% of all cancer diagnoses.